Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of AÎ2 amyloidosis
نویسندگان
چکیده
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis."
منابع مشابه
Anti-ApoE antibody given after plaque onset decreases AÎ2 accumulation and improves brain function in a mouse model of AÎ2 amyloidosis
ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. Apolipoprotein E (apoE) is the strongest known genetic risk factor for late onset Alzheimer's disease (AD). It influences amyloid- (A) clearance and aggregation, which likely contributes in large part to its role in AD pathogenesis. We recently found that HJ6.3, a m...
متن کاملAnti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for Alzheimer's disease (AD). The influence of apoE on amyloid β (Aβ) accumulation may be the major mechanism by which apoE affects AD. ApoE interacts with Aβ and facilitates Aβ fibrillogenesis in vitro. In addition, apoE is one of the protein components in plaques. We hypothesized that certain anti-apoE antibodies, simi...
متن کاملHaploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-Î2 amyloidosis
Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis." The 4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD). Evidence suggests that the effect of apoE isoforms on amyloid- (A) accumulation in the brain plays a critical role in AD pathogenesis. Like in humans, apoE4 expression in ani...
متن کاملHaploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis.
The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer's disease (AD). Evidence suggests that the effect of apoE isoforms on amyloid-β (Aβ) accumulation in the brain plays a critical role in AD pathogenesis. Like in humans, apoE4 expression in animal models that develop Aβ amyloidosis results in greater Aβ and amyloid deposition than with apoE3 expr...
متن کاملAnti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.
Apolipoprotein E (apoE) is the strongest known genetic risk factor for late onset Alzheimer's disease (AD). It influences amyloid-β (Aβ) clearance and aggregation, which likely contributes in large part to its role in AD pathogenesis. We recently found that HJ6.3, a monoclonal antibody against apoE, significantly reduced Aβ plaque load when given to APPswe/PS1ΔE9 (APP/PS1) mice starting before ...
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تاریخ انتشار 2015